Recognition of Hg2+ion through restricted imine isomerization: crystallographic evidence and imaging in live cells
| Title | Recognition of Hg2+ion through restricted imine isomerization: crystallographic evidence and imaging in live cells |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Mandal, AKumar, Suresh, M, Das, P, Suresh, E, Baidya, M, Ghosh, SK, Das, A |
| Journal | Organic Letters |
| Volume | 14 |
| Issue | 12 |
| Pagination | 2980–2983 |
| Date Published | JUN |
| Abstract | A newly synthesized imine-based receptor (L) showed remarkable specificity toward the Hg2+ ion in aqueous media over other metal ions. Coordination of L to Hg2+ induces a turn-on fluorescence response. This was explained based on the restricted imine isomerization along with PET on coordination to Hg2+. X-ray structural evidence tends to favor a C–C bond rotation rather than C═N isomerization for adopting a favorable conformation in L for coordination to Hg2+. This reagent could be used for imaging the accumulation of Hg2+ ions in HeLa cells. |
| DOI | 10.1021/ol3009733 |
| Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.142 |
Divison category:
Organic Chemistry