Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

Title Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products
Publication TypeJournal Article
Year of Publication2019
AuthorsThorat, SS
Secondary AuthorsKontham, R
JournalOrganic & Biomolecular Chemistry
Volume17
Issue31
Pagination7270-7292
Date PublishedAUG
Type of ArticleReview
Abstract

Oxaspirolactones are ubiquitous structural motifs found in natural products and synthetic molecules with a diverse biochemical and physicochemical profile, and represent a valuable target in natural product chemistry and medicinal chemistry. Since the 1970s, numerous innovative synthetic methodologies have been reported for these scaffolds in the context of expanding the range of potential building blocks, catalysts, and modes of transformations (racemic or asymmetric protocols). This review focuses on a broad spectrum of approaches toward the synthesis of oxaspirolactones and their potential application in the total synthesis of biologically relevant natural products starting from the first disclosure to the latest report.

DOI10.1039/c9ob01212e
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.49

Divison category: 
Organic Chemistry

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