Radio-frequency triggered heating and drug release using doxorubicin-loaded LSMO nanoparticles for bimodal treatment of breast cancer
| Title | Radio-frequency triggered heating and drug release using doxorubicin-loaded LSMO nanoparticles for bimodal treatment of breast cancer |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Kulkarni, VM, Bodas, D, Dhoble, D, Ghormade, V, Paknikar, K |
| Journal | Colloids and Surfaces B-Biointerfaces |
| Volume | 145 |
| Pagination | 878-890 |
| Date Published | SEP |
| Abstract | Radio-frequency responsive nanomaterials combined with drugs for simultaneous hyperthermia and drug delivery are potential anti-cancer agents. In this study, chitosan coated La0.7Sr0.3MnO3 nanoparticles (C-LSMO NPs) were synthesized and characterized by X-ray diffraction, dynamic light scattering, Fourier transform infra red spectroscopy, vibrating sample magnetometer, scanning electron and atomic force microscopy, Under low radio-frequency (365 kHz, RF), C-LSMO NPs (90 nm) showed good colloidal stability (+22 mV), superparamagnetic nature (15.4 emu/g) and heating capacity (57.4W/g SAR value). Chitosan facilitated doxorubicin entrapment (76%) resulted in DC-LSMO NPs that showed drug release upon a 5 min RF exposure. MCF-7 and MDA-MB-231 cancer cells responded to a 5 min RF exposure in the presence of bimodal DC-LSMO NPs with a significant decrease in viability to 73% and 88% (Pearson correlation, r = 1, P |
| DOI | 10.1016/j.colsurfb.2016.06.010 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.902 |
Divison category:
Polymer Science & Engineering
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