Radical-mediated dehydrative preparation of cyclic imides using (NH4)(2)S2O8-DMSO: application to the synthesis of vernakalant
| Title | Radical-mediated dehydrative preparation of cyclic imides using (NH4)(2)S2O8-DMSO: application to the synthesis of vernakalant |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Garad, DN, Tanpure, SD, Mhaske, SB |
| Journal | Beilstein Journal of Organic Chemistry |
| Volume | 11 |
| Pagination | 1008-1016 |
| Date Published | JUN |
| ISSN | 1860-5397 |
| Keywords | APS-DMSO, imides, practical synthesis, radical-mediated, vernakalant |
| Abstract | Ammonium persulfate-dimethyl sulfoxide (APS-DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant. |
| DOI | 10.3762/bjoc.11.113 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.697 |
Divison category:
Organic Chemistry