Protecting group directed ring-closing metathesis (RCM): the first total synthesis of an anti-malarial nonenolide
| Title | Protecting group directed ring-closing metathesis (RCM): the first total synthesis of an anti-malarial nonenolide |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Mohapatra, DK, Ramesh, DK, Giardello, MA, Chorghade, MS, Gurjar, MK, Grubbs, RH |
| Journal | Tetrahedron Letters |
| Volume | 48 |
| Issue | 14 |
| Pagination | 2621-2625 |
| Date Published | APR |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | 1, 2-O-isopropylidene, anti-malarial agent, D-glyceraldehyde, Nonenolide, Ring-closing metathesis, Yamaguchi esterification |
| Abstract | The first synthesis of a newly found naturally occurring anti-malarial nonenolide is described. A pivotal step in the synthesis is the ring-closing metathesis of a dienoic ester prepared by coupling an acid and alcohol that were stereoselectively synthesized from (S)-alpha-hydroxy-gamma-butyrolactone and 1,2-O-isopropylidene D-glyceraldchyde, respectively. (c) 2007 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2007.02.040 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry