Proline-catalyzed sequential syn-mannich and [4+1]-annulation cascade reactions to form densely functionalized pyrrolidines
| Title | Proline-catalyzed sequential syn-mannich and [4+1]-annulation cascade reactions to form densely functionalized pyrrolidines |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Aher, RD, B. Kumar, S, Sudalai, A |
| Journal | Journal of Organic Chemistry |
| Volume | 80 |
| Issue | 3 |
| Pagination | 2024-2031 |
| Date Published | FEB |
| ISSN | 0022-3263 |
| Abstract | A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described. The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Coreys sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner. |
| DOI | 10.1021/jo5028886 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.785 |
Divison category:
Chemical Engineering & Process Development