Proline catalyzed direct diastereoselective 6-enolexo aldolization: toward the synthesis of the imino sugar DNJ

TitleProline catalyzed direct diastereoselective 6-enolexo aldolization: toward the synthesis of the imino sugar DNJ
Publication TypeJournal Article
Year of Publication2010
AuthorsKumar, I, Rode, CV
JournalTetrahedron-Asymmetry
Volume21
Issue21-22
Pagination2703-2708
Date PublishedNOV
ISSN0957-4166
Abstract

A L-proline catalyzed direct diastereoselective 6-enolexo aldolization reaction of differentiating dialdehydes derived from tartaric acid is presented This organocatalytic approach provides high levels of synselectivity (dr > 10 1) with the stereocontrolled C-C bond formation between C4 and C5 intramolecularly which can serve to synthesize Imino-sugar skeleton quickly (C) 2010 Elsevier Ltd All rights reserved

DOI10.1016/j.tetasy.2010.10.024
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.484
Divison category: 
Chemical Engineering & Process Development