Proline-catalyzed alpha-aminooxylation of beta-amino aldehydes: access to enantiomerically pure syn- and anti-3-amino-3-aryl-1,2-alkanediols
| Title | Proline-catalyzed alpha-aminooxylation of beta-amino aldehydes: access to enantiomerically pure syn- and anti-3-amino-3-aryl-1,2-alkanediols |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Venkataramasubramanian, V, Kiran, INChaitha, Sudalai, A |
| Journal | Synlett |
| Volume | 26 |
| Issue | 3 |
| Pagination | 355-358 |
| Date Published | FEB |
| ISSN | 0936-5214 |
| Keywords | amino aldehydes, Asymmetric synthesis, catalysis, diastereoselectivity, Enantioselectivity, Natural product |
| Abstract | A new synthetic method for enantioselective synthesis of syn 3-amino-3-aryl-1,2-alkanediols via praline catalyzed alpha-aminaoxn y ylation of beta-amino aldehydes des are described. This methodology is successfully applied to a concise and protecting group-free asymmetric synthesis of (-)-cytoxazone (+)-epi-cytoxazone and formal synthesis of N-thiolated 2-oxazolidinone. |
| DOI | 10.1055/s-0034-1379735 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.323 |
Divison category:
Chemical Engineering & Process Development