Problem solving and environmentally benign approach toward diversity oriented synthesis of novel 2-amino-3-phenyl (or Alkyl) sulfonyl-4H-chromenes at ambient temperature
| Title | Problem solving and environmentally benign approach toward diversity oriented synthesis of novel 2-amino-3-phenyl (or Alkyl) sulfonyl-4H-chromenes at ambient temperature |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Pandit, KS, Kupwade, RV, Chavan, PV, Desai, UV, Wadgaonkar, PP, Kodam, KM |
| Journal | ACS Sustainable Chemistry & Engineering |
| Volume | 4 |
| Pagination | 3450-3464 |
| Date Published | JUN |
| ISSN | 2168-0485 |
| Keywords | 2-Amino-3-methylsulfonyl-4H-chromenes, 2-Amino-3-phenylsulfonyl-4H-chromenes, diethylamine, green chemistry, Multicomponent synthesis, organocatalyst |
| Abstract | A problem solving, environmentally benign, and diversity oriented protocol has been described for multi component synthesis of medicinally privileged 2-amino-3-phenyl (or methyl) sulfonyl-4H-chromenes by one-pot, three component condensation among aldehydes, phenyl (or methyl) sulphonyl acetonitrile, and alpha-naphthol, 3-dimethylamino phenol, 4-hydroxy-N-methyl-quinoline-2-one as well as 4-hydroxycarbazole, using diethylamine as an efficient organo catalyst. The catalyst employed is commercially available, inexpensive, and nontoxic. Ambient reaction conditions, very high yields, wide scope, and avoidance of conventional isolation as well as chromatographic purification have improved the practical utility of this protocol manifold. |
| DOI | 10.1021/acssuschemeng.6b00484 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 5.267 |
Divison category:
Polymer Science & Engineering