Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins br

TitlePostmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins br
Publication TypeJournal Article
Year of Publication2022
AuthorsKalshetti, RG, Rajput, R, Motiwala, Z, D. Reddy, S, Kulkarni, KA, Ramana, CV
JournalBioorganic & Medicinal Chemistry Letters
Volume77
Pagination129022
Date PublishedDEC
Type of ArticleArticle
ISSN0960-894X
KeywordsCDC Coupling, GBT-440 (Voxelotor), Rh(III) catalysis, sickle cell anemia
Abstract

The directed Rh(III)-catalyzed cross dehydrogenative coupling of the pyrazole unit of the GBT-440 scaffold has been explored with simple as well as conjugated olefins to synthesize post-functionalized GBT-440 analogues. The screening of these synthesized compounds for improving the oxygen binding efficiency of the hemoglobin isolated from the sickled red blood cells revealed that some of these compounds are as good as GBT-440.

DOI10.1016/j.bmcl.2022.129022
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.940

Divison category: 
Biochemical Sciences
Organic Chemistry
Database: 
Web of Science (WoS)

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