Plasma-derived extracellular vesicles reveal galectin-3 binding protein as potential biomarker for early detection of glioma
| Title | Plasma-derived extracellular vesicles reveal galectin-3 binding protein as potential biomarker for early detection of glioma |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Rana, R, Chauhan, K, Gautam, P, Kulkarni, M, Banarjee, R, Chugh, P, Chhabra, SSingh, Acharya, R, Kalra, SKumar, Gupta, A, Jain, S, Ganguly, NKumar |
| Journal | Frontiers in Oncology |
| Volume | 11 |
| Pagination | 778754 |
| Date Published | NOV 26 |
| Type of Article | Article |
| ISSN | 2234-943X |
| Keywords | blood-based biomarker, early detection, galectin-3 binding protein, plasma-derived extracellular vesicles, proteomics |
| Abstract | {Gliomas are the most common type of the malignant brain tumor, which arise from glial cells. They make up about 40% of all primary brain tumors and around 70% of all primary malignant brain tumors. They can occur anywhere in the central nervous system (CNS) and have a poor prognosis. The average survival of glioma patients is approximately 6-15 months with poor aspects of life. In this edge, identification of proteins secreted by cancer cells is of special interest because it may provide a better understanding of tumor progression and provide early diagnosis of the diseases. Extracellular vesicles (EVs) were isolated from pooled plasma of healthy controls (n=03) and patients with different grades of glioma (Grade I or II or III |
| DOI | 10.3389/fonc.2021.778754 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.244 |
Divison category:
Biochemical Sciences