Photocatalytic oxidation of α-substituted amines to lactams/amides
| Title | Photocatalytic oxidation of α-substituted amines to lactams/amides |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Kumar, M, Kumar, P, Das, U |
| Journal | Advanced Synthesis & Catalysis |
| Volume | 367 |
| Issue | 3 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 1615-4150 |
| Keywords | alpha-Aminonitriles, Decyanation, Dioxetanimine, Photocatalytic, pyrrolidine |
| Abstract | We, herein, report a base free, photocatalytic decyanation of alpha-aminonitriles. A range of amides and lactams were obtained in 52-95% yields. Control experiments indicate O2 as an amide/lactam oxygen source and the reaction (lactam formation) follows radical pathway via dioxetanimine species. This methodology also applied for alpha-ester/aldehyde substituted pyrrolidines in the presence of a base, probably via decarboxylation pathway. |
| DOI | 10.1002/adsc.202400871 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.4 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)