Perspectives on leishmania species and stage-specific adaptive mechanisms
| Title | Perspectives on leishmania species and stage-specific adaptive mechanisms |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Subramanian, A, Sarkar, RRup |
| Journal | Trends In Parasitology |
| Volume | 34 |
| Issue | 12 |
| Pagination | 10.1016/j.pt.2018.09.004 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 1471-4922 |
| Abstract | The hurdles in drug and vaccine development pipelines for leishmaniasis, a complex, multifaceted disease, are largely due to the digenetic lifecycle, differential clinical manifestations of the parasite, and the incomplete understanding of its adaptations within its hosts. Here, we discuss the distinct computational and experimental techniques employed to identify the species and stage-specific adaptive mechanisms at different levels of biological organization, the progress made so far, and limitations in comprehending leishmaniasis as a systems biology disease. Based on the available perspectives, we also provide suggestions and requirements to tackle the growing challenges for bridging the genotype with the phenotype. A systems perspective can be instrumental in understanding the complexities of the disease and can provide insights for targeted control. |
| DOI | 10.1016/j.pt.2018.09.004 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 7.929 |
Divison category:
Chemical Engineering & Process Development
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