Pd(II)-catalyzed intramolecular tandem olefin amidation/C-H activation protocol for the syntheses of the protoberberine class of natural products
| Title | Pd(II)-catalyzed intramolecular tandem olefin amidation/C-H activation protocol for the syntheses of the protoberberine class of natural products |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Garad, DN, Mhaske, SB |
| Journal | Organic Letters |
| Volume | 18 |
| Issue | 15 |
| Pagination | 3862-3865 |
| Date Published | AUG |
| ISSN | 1523-7060 |
| Abstract | A Pd(II)-catalyzed intramolecular tandem olefin amidation/C-H activation protocol has been developed for the synthesis of an 8-oxoprotoberberine core. It was successfully applied for the syntheses of (+/-)-8-oxocanadine, (+/-)-8-oxotetrahydropalmitine, and (+/-)-8-oxostylopine, which can be easily converted to the respective protoberberine natural products. The short synthetic route demonstrated would be useful for the synthesis of a large number of natural products and their analogues featuring a protoberberine scaffold. |
| DOI | 10.1021/acs.orglett.6b01868 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Organic Chemistry