[Pd]-mediated omega-alkynone cycloisomerization approach for the central tetrahydropyran unit and the synthesis of C(31)-C(48) fragment of aflastatin A
| Title | [Pd]-mediated omega-alkynone cycloisomerization approach for the central tetrahydropyran unit and the synthesis of C(31)-C(48) fragment of aflastatin A |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Narute, SB, Kiran, NChandra, Ramana, CV |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 9 |
| Issue | 15 |
| Pagination | 5469-5475 |
| Date Published | APR |
| ISSN | 1477-0520 |
| Abstract | A concise assembly of the central tetrahydropyran unit of aflastatin A featuring a Pd-mediated alkynone cycloisomerization to provide a glycal and its subsequent stereoselective hydroboration to deliver the requisite stereochemistry at C(33) and C(34) centers is documented. |
| DOI | 10.1039/c1ob05251a |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.85 |
Divison category:
Organic Chemistry