Palladium-catalyzed oxidative cyclization of ?-allenols in the presence of TBN: access to 3(2H)-furanones

TitlePalladium-catalyzed oxidative cyclization of ?-allenols in the presence of TBN: access to 3(2H)-furanones
Publication TypeJournal Article
Year of Publication2023
AuthorsGhotekar, GS, Shinde, RA, Saswade, SS, Muthukrishnan, M
JournalJournal of Organic Chemistry
Volume88
Issue7
Pagination4112-4122
Date PublishedAPR
Type of ArticleArticle
ISSN0022-3263
KeywordsAlternatively, conditions, cumbersome workup, intramolecular electrophilic, multiple reaction steps, noted examples
Abstract

A new palladium-catalyzed oxidative cyclization of alpha-allenols is described. The readily accessible alpha-allenols participate in intra-molecular oxidative cyclization in the presence of TBN to grant access to multisubstituted 3(2H)-furanones, which are common motifs in several biologically important natural products and pharmaceuticals.

DOI10.1021/acs.joc.2c024574112
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

4.198

Divison category: 
Organic Chemistry
Database: 
Web of Science (WoS)

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