P2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic acid as acylating agent
| Title | P2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic acid as acylating agent |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Kalshetti, RG, Mandle, RD, Kamble, SP, Sudalai, A |
| Journal | Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry |
| Volume | 59 |
| Issue | 12 |
| Pagination | 1861-1867 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 0376-4699 |
| Keywords | 4-methoxyacetophenone, Carboxylic acid, Friedel-Crafts acylations, phosphorus pentoxide |
| Abstract | P2O5 has been found to be a highly efficient and environmental friendly catalyst for the liquid-phase acylation of activated aromatic substrates giving aromatic ketones (45-93%) in a regioselective manner. Both aromatic and aliphatic carboxylic acids can be employed as acylating source. The process is particularly demonstrated at 100 g scale in the case of anisole and acetic acid to produce 4-methoxyacetophenone. |
| Type of Journal (Indian or Foreign) | Indian |
| Impact Factor (IF) | 0.388 |
Divison category:
Chemical Engineering & Process Development