Organocatalytic enantioselective direct vinylogous michael addition of alpha,beta-unsaturated gamma-butyrolactam to beta-acyl acrylates and 1,2-diacylethylenes
| Title | Organocatalytic enantioselective direct vinylogous michael addition of alpha,beta-unsaturated gamma-butyrolactam to beta-acyl acrylates and 1,2-diacylethylenes |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Chen, Y-R, Das, U, Liu, M-H, Lin, W |
| Journal | Journal of Organic Chemistry |
| Volume | 80 |
| Issue | 3 |
| Pagination | 1985-1992 |
| Date Published | FEB |
| ISSN | 0022-3263 |
| Abstract | A highly efficient Michael addition of alpha,beta-unsaturated gamma-butyrolactam to various beta-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters. |
| DOI | 10.1021/jo5027047 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.785 |
Divison category:
Organic Chemistry