Organocatalytic enantioselective approach to the synthesis of verbalactone and (R)-massoialactone

TitleOrganocatalytic enantioselective approach to the synthesis of verbalactone and (R)-massoialactone
Publication TypeJournal Article
Year of Publication2011
AuthorsHarbindu, A, Kumar, P
JournalSynthesis-Stuttgart
Issue12
Pagination1954-1959
Date PublishedJUN
ISSN0039-7881
Keywordsalpha-aminoxylation, Horner-Wadsworth-Emmons olefination, L-proline, massoialactone, Ring-closing metathesis, verbalactone, Yamaguchi macrolactonization
Abstract

The organocatalytic enantioselective synthesis of verbalactone and (R)-massoialactone is described. The requisite stereogenic centers of the target molecules were constructed using L-proline-catalyzed alpha-aminoxylation and Horner-Wadsworth-Emmons (HWE) olefination. Yamaguchi macrolactonization and ring-closing metathesis were employed as key steps in the syntheses.

DOI10.1055/s-0030-1260051
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.466
Divison category: 
Organic Chemistry