Organocatalytic [4+1]-annulation approach for the synthesis of densely functionalized pyrazolidine carboxylates
| Title | Organocatalytic [4+1]-annulation approach for the synthesis of densely functionalized pyrazolidine carboxylates |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Lalwani, KG, Aher, RD, Sudalai, A |
| Journal | RSC Advances |
| Volume | 5 |
| Issue | 80 |
| Pagination | 65554-65559 |
| Date Published | JUL |
| ISSN | 2046-2069 |
| Abstract | A novel one-pot [4+1]-annulation process for the asymmetric synthesis of densely functionalized pyrazolidine carboxylates is described. The in situ generated gamma-hydrazino-alpha,beta-unsaturated ester obtained via proline catalysis acts as a four-atom component, and Corey's sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrazolidine carboxylate units in a highly enantio- and diastereoselective fashion. |
| DOI | 10.1039/c5ra09583b |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.289 |
Divison category:
Chemical Engineering & Process Development