Novel synthesis of highly functionalized pyrazolines and pyrazoles by triphenylphosphine mediated reaction of dialkyl azodicarboxylate with allenic esters
| Title | Novel synthesis of highly functionalized pyrazolines and pyrazoles by triphenylphosphine mediated reaction of dialkyl azodicarboxylate with allenic esters |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Nair, V, Biju, AT, Mohanan, K, Eringathodi, S |
| Journal | Organic Letters |
| Volume | 8 |
| Issue | 11 |
| Pagination | 2213–2216 |
| Date Published | MAY |
| Type of Article | Article |
| Abstract | Reaction of the Huisgen zwitterion, derived from triphenylphosphine and dialkyl azodicarboxylate, with allenic esters affords highly functionalized pyrazolines and pyrazoles. The crystal structure of pyrazoline derivative 7a showed extensive C−H···O interactions. Pyrazole formation proceeds via a novel nitrogen to carbon migration of the carboalkoxy group. |
| DOI | 10.1021/ol0604623 |
| Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Organic Chemistry