Nickel-catalyzed N-vinylation of heteroaromatic amines via C-H bond activation

TitleNickel-catalyzed N-vinylation of heteroaromatic amines via C-H bond activation
Publication TypeJournal Article
Year of Publication2017
AuthorsLandge, VG, Rana, J, Subaramanian, M, Balaraman, E
JournalOrganic & Biomolecular Chemistry
Volume15
Issue33
Pagination 6896-6900
Date PublishedSEP
Type of ArticleArticle
ISSN1477-0520
KeywordsAlkylation, Amination Reactions, Anilines, Aryl Chlorides, halides, Monoarylation, O Bonds, Precatalyst, Pyrimidines, Removeble Directing Group
Abstract

Here, we report a ligand- and reductant-free nickel-catalyzed N-vinylation of heteroaromatic amines using biorenewable p-cymene as a solvent. This unprecedented cross-coupling strategy has high functional group tolerance (halides, alkoxy, cyano, chiral motif, etc.) and proceeded via C-H bond activation.
DOI10.1039/c7ob01791j
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)

3.559
Divison category: 
Catalysis and Inorganic Chemistry