NHC/Phosphite Nickel(II) Precatalysts for the C-N Cross-Coupling of (Hetero)Aryl Chlorides under Mild Conditions
| Title | NHC/Phosphite Nickel(II) Precatalysts for the C-N Cross-Coupling of (Hetero)Aryl Chlorides under Mild Conditions |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Darandale, NR, John, ME, Moggach, SA, Sawant, DN, Koutsantonis, GA, Dorta, R, Stewart, SG |
| Journal | ORGANIC LETTERS |
| Volume | 27 |
| Issue | 37 |
| Pagination | 10526-10531 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 1523-7060 |
| Abstract | We report the synthesis of three nickel complexes based on Ni(NHC)[P(OR)3](Ar)Cl and their application in C(sp 2)-N cross-coupling reactions. Reactions involving secondary amines proceeded at room temperature, while anilines and primary alkyl amines coupled under mild heating. The reported complexes are air-stable as solids, operate at low catalytic loading, and do not require an exogenous ligand. Mechanistic studies suggest both free and Ni-bound phosphite are present during the reaction and that an isolated [Ni(NHC)(amine)(Ar)Cl] complex could be an on-cycle, catalytically active species. |
| DOI | 10.1021/acs.orglett.5c03230 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.6 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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