NHC-catalyzed enantioselective synthesis of tetracyclic δ-lactones by (4+2) annulation of ortho-quinodimethanes with activated ketones
| Title | NHC-catalyzed enantioselective synthesis of tetracyclic δ-lactones by (4+2) annulation of ortho-quinodimethanes with activated ketones |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Sarkar, D, Barik, S, Shee, S, Gonnade, RG, Biju, AT |
| Journal | Organic Letters |
| Volume | 25 |
| Issue | 43 |
| Pagination | 7852-7857 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 1523-7060 |
| Abstract | The N-heterocyclic carbene (NHC)-catalyzed generation of ortho-quinodimethanes (o-QDMs) from 9H-fluorene-1-carbaldehydes followed by the interception with activated ketones resulting in the enantioselective synthesis of tetracyclic delta-lactones is presented. High diastereoselectivity of products, remote C-(sp(3))-H functionalization, broad substrate scope, and mild reaction conditions are the notable features of the present (4 + 2) annulation. |
| DOI | 10.1021/acs.orglett.3c03076 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 5.2 |
Divison category:
Physical and Materials Chemistry
Database:
Web of Science (WoS)