New enantioselective synthesis of the anticonvulsant drug pregabalin (lyrica) based on a hydrolytic kinetic resolution method
| Title | New enantioselective synthesis of the anticonvulsant drug pregabalin (lyrica) based on a hydrolytic kinetic resolution method |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Mujahid, M, Muthukrishnan, M |
| Journal | Chirality |
| Volume | 25 |
| Issue | 12 |
| Pagination | 965-969 |
| Date Published | DEC |
| ISSN | 0899-0042 |
| Keywords | anticonvulsant drug, Hydrolytic kinetic resolution, pregabalin |
| Abstract | A practical and efficient enantioselective synthesis of the anticonvulsant drug pregabalin is described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and a source of chirality. Chirality 25:965-969, 2013. (c) 2013 Wiley Periodicals, Inc. |
| DOI | 10.1002/chir.22253 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.724 |
Divison category:
Organic Chemistry