Nevirapine loaded core shell gold nanoparticles by double emulsion solvent evaporation: invitro and in vivo evaluation
| Title | Nevirapine loaded core shell gold nanoparticles by double emulsion solvent evaporation: invitro and in vivo evaluation |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Dalvi, BR, Siddiqui, EA, Syed, AS, Velhal, SM, Ahmad, A, Bandivdekar, AB, Devarajan, PV |
| Journal | Current Drug Delivery |
| Volume | 13 |
| Issue | 7 |
| Pagination | 1071-1083 |
| Date Published | JAN |
| Abstract | Background: HIV/AIDS is a macrophage resident infection localized in the reticuloendothelial system and remote locations of brain and bone marrow. We present core shell nanoparticles of gold(AuNPs) and nevirapine(NVP) for targeted delivery to the multiple HIV reservoirs. The aim of the study was to design core shell NVP loaded AuNPs with high drug loading and to evaluate biodistribution of the nanoparticles in possible HIV reservoirs in vivo. A specific objective was to assess the possible synergy of AuNPs with NVP on anti-HIV activity in vitro. Method: Core shell nanoparticles were prepared by double emulsion solvent evaporation method and characterized. Results: Glyceryl monostearate-nevirapine-gold nanoparticles(GMS-NVP-AuNPs) revealed high entrapment efficiency (> 70%), high loading (similar to 40%), particle size |
| DOI | 10.2174/1567201813666160114093005 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.446 |
Divison category:
Biochemical Sciences
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