N-heterocyclic carbene-catalyzed hydroacylation of unactivated double bonds
| Title | N-heterocyclic carbene-catalyzed hydroacylation of unactivated double bonds |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Hirano, K, Biju, AT, Piel, I, Glorius, F |
| Journal | Journal of the American Chemical Society |
| Volume | 131 |
| Issue | 40 |
| Pagination | 14190–14191 |
| Date Published | SEP |
| Abstract | An intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated double bonds is reported. Systematic variation of the catalyst structure revealed an N-mesitylthiazolylidene annulated with a seven-membered ring to be especially reactive. This NHC enables a unique C−C bond-forming reaction to afford substituted chroman-4-ones in moderate to excellent yields, even ones containing all-carbon quaternary centers. |
| DOI | 10.1021/ja906361g |
| Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 9.019 |
Divison category:
Organic Chemistry