Multi-purpose synthetic alpha-amino acid featuring coumarin and ureidopyrimidinone motifs on its backbone: Synthesis and peptide formation
| Title | Multi-purpose synthetic alpha-amino acid featuring coumarin and ureidopyrimidinone motifs on its backbone: Synthesis and peptide formation |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Rashid, PP, Sanjayan, GJ |
| Journal | Tetrahedron Letters |
| Volume | 93 |
| Pagination | 153695 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | Fluorescent amino acids, Fluorescent Peptides, Quadruple hydrogen bonding, Unnatural amino acids, Ureidopyrimidinone |
| Abstract | Herein we report a synthetic a-amino acid featuring intensely fluorescent coumarin moiety and a strongly self-assembling ureidopyrimidinone (UPy) motif. This two-in-one synthetic amino acid, displaying both fluorescence and self-assembling property, has been synthesized in four easy steps starting from commercially available inexpensive starting materials. Suitably protected amino acid has been incorporated into various peptide sequences, following solution-phase peptide coupling protocols, to demonstrate its synthetic feasibility.(c) 2022 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2022.153695 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.032 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)