Modular synthesis of cyclic peptidomimetics inspired by gamma-turns
| Title | Modular synthesis of cyclic peptidomimetics inspired by gamma-turns |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Ramanathan, SK, Keeler, J, Lee, HL, D. Reddy, S, Lushington, G, Aube, J |
| Journal | Organic Letters |
| Volume | 7 |
| Issue | 6 |
| Pagination | 1059-1062 |
| Date Published | MAR |
| Abstract | A series of peptidomimetics based on a gamma-turn motif were synthesized using a modular approach, in which N-protected piperidones were reacted with a selection of 2-hydroxyalkyl azides derived from common L-amino acids. Hydrolysis of the initially formed iminium ethers afforded the targeted series of substituted 1,4-diazepin-5-ones. |
| DOI | 10.1021/ol047323a |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Organic Chemistry