A model is presented for a continuous multistage liquid phase cyclohexane oxidation reactors-in-series network, which uses, unlike previous efforts, a closed form rate model derived on the basis of the well-known free-radical kinetic mechanism of the oxidation reaction leading to a more generalized representation of the oxygen dependence of the rate. The model calculates the required transport and hydrodynamic parameters by one of the best available set of correlations shown earlier to be successfully used in cyclohexane oxidation in a well-designed laboratory reactor. Process sensitivities with regard to variables such as air rate, residence time, head pressure, inlet air composition and sparger configuration have been predicted. Some of these trends compared very well with the limited published experimental data in a three (351) agitated and sparged tank-in-series reactor system, thus partially validating the model. The model has highlighted a fairly generalized way of correlating performance data from a given reactor, namely in terms of a yield-conversion characteristic which can change depending on the mass transfer efficiency and the effective kinetics. Hence, it can aid in plant monitoring and optimization. It has also been shown how to use the same as an aid in preliminary scale-up studies based on laboratory or pilot plant reactor performance data. (C) 2004 Elsevier B.V. All rights reserved.