Mizoroki-Heck reaction of 1,2-disubstituted aryl alkenes: variables of synthesis, solvent and ligand modulation of reactivity
| Title | Mizoroki-Heck reaction of 1,2-disubstituted aryl alkenes: variables of synthesis, solvent and ligand modulation of reactivity |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Bangar, PG, Jawalkar, PR, Dumbre, SR, Raut, PK, Patil, DJ, Tv, N, Sudhakaran, S, Iyer, S |
| Journal | Synthetic Communications |
| Volume | 50 |
| Issue | 24 |
| Pagination | 3796-3803 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 0039-7911 |
| Keywords | 12-Disubstituted aryl alkenes, 400, ligand effect, Mizoroki-Heck reaction, PEG 200, TBABr |
| Abstract | Reaction of aryl iodides with 1,2-disubstituted aryl alkenes in the presence of TBABr/TBACl gave high yields of the Mizoroki-Heck product. Phosphine ligands were used for the modulation of reactivity and stereoselectivity, for the reaction of 4-iodoanisole with cinnamaldehyde. tert-Bu3P.HBF(4)gave the highest E:Z ratio of 1:0.08. The use of PEG-200 and PEG-400 as solvent could activate the reaction of aryl iodides with various 1,2-disubstituetd aryl alkenes. |
| DOI | 10.1080/00397911.2020.1811986, Early Access Date = AUG 2020 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.796 |
Divison category:
Organic Chemistry