Metal-free, Tf2NH-catalyzed 1, 6-conjugate addition of imidazopyridine to para-quinone methides: easy access to C3-functionalized triarylmethane imidazopyridine
| Title | Metal-free, Tf2NH-catalyzed 1, 6-conjugate addition of imidazopyridine to para-quinone methides: easy access to C3-functionalized triarylmethane imidazopyridine |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Khonde, NS, Said, MS, Sabane, JK, Gajbhiye, JM, Kumar, P |
| Journal | Tetrahedron |
| Volume | 101 |
| Pagination | 132510 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0040-4020 |
| Keywords | 1, 6-Conjugate addition, Bronsted acid, C3-functionalization, Imidazopyridine, para-Quinone methide |
| Abstract | An inexpensive and commercially available Tf2NH-catalyzed 1,6-conjugate addition of imidazopyridine (IMPY) heterocycles to para-quinone methides (p-QMs) is reported. The present transformation provides a diverse class of C3-functionalized triarylmethanes heterocyclic derivatives of imidazopyridine. These metal-free transformations provided a very broad substrate scope of conjugate addition product with a high yield up to 97% within a short duration. (C) 2021 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2021.132510 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.457 |
Divison category:
Organic Chemistry