"Metal-free'' synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives

Title"Metal-free'' synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives
Publication TypeJournal Article
Year of Publication2018
AuthorsB. Kumar, S, Gadakh, S, Sudalai, A
JournalTetrahedron Letters
Volume59
Issue24
Pagination2365-2367
Date PublishedJUN
ISSN0040-4039
KeywordsIntramolecular cycloaddition, Regioselective, Tandem azidation, triazoles
Abstract

An efficient ``one-pot'' method for the synthesis of substituted 1,2,3-triazole derivatives in excellent yields as single regioisomer is reported. The key transformation involves an atom-efficient tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of acrylate derivatives on treatment with NaN3 in DMF under mild conditions. (C) 2018 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2018.05.020
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.193

Divison category: 
Chemical Engineering & Process Development

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