"Metal-free'' synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives
| Title | "Metal-free'' synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | B. Kumar, S, Gadakh, S, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 59 |
| Issue | 24 |
| Pagination | 2365-2367 |
| Date Published | JUN |
| ISSN | 0040-4039 |
| Keywords | Intramolecular cycloaddition, Regioselective, Tandem azidation, triazoles |
| Abstract | An efficient ``one-pot'' method for the synthesis of substituted 1,2,3-triazole derivatives in excellent yields as single regioisomer is reported. The key transformation involves an atom-efficient tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of acrylate derivatives on treatment with NaN3 in DMF under mild conditions. (C) 2018 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2018.05.020 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.193 |
Divison category:
Chemical Engineering & Process Development
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