Mechanical downsizing of a gadolinium(iii)-based metal-organic framework for anticancer drug delivery
Title | Mechanical downsizing of a gadolinium(iii)-based metal-organic framework for anticancer drug delivery |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Kundu, T, Mitra, S, Patra, P, Goswami, A, Diaz, DDiaz, Banerjee, R |
Journal | Chemistry-A European Journal |
Volume | 20 |
Issue | 33 |
Pagination | 10514-10518 |
Date Published | AUG |
ISSN | 0947-6539 |
Keywords | ball-milling, doxorubicin, drug delivery, metal-organic frameworks, nanocarriers |
Abstract | A Gd-III-based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9x1.2nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (>90min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12wt%) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release. |
DOI | 10.1002/chem.201402244 |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 6.35 |