Mechanical downsizing of a gadolinium(iii)-based metal-organic framework for anticancer drug delivery

TitleMechanical downsizing of a gadolinium(iii)-based metal-organic framework for anticancer drug delivery
Publication TypeJournal Article
Year of Publication2014
AuthorsKundu, T, Mitra, S, Patra, P, Goswami, A, Diaz, DDiaz, Banerjee, R
JournalChemistry-A European Journal
Volume20
Issue33
Pagination10514-10518
Date PublishedAUG
ISSN0947-6539
Keywordsball-milling, doxorubicin, drug delivery, metal-organic frameworks, nanocarriers
Abstract

A Gd-III-based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9x1.2nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (>90min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12wt%) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release.

DOI10.1002/chem.201402244
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)6.35
Divison category: 
Physical and Materials Chemistry