Lewis acid catalyzed cascade annulation of alkynols with alpha-ketoesters: a facile access to gamma-spiroketal-gamma-lactones
| Title | Lewis acid catalyzed cascade annulation of alkynols with alpha-ketoesters: a facile access to gamma-spiroketal-gamma-lactones |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Kambale, DA, Thorat, SS, Pratapure, MS, Gonnade, RG, Kontham, R |
| Journal | Chemical Communications |
| Volume | 53 |
| Issue | 49 |
| Pagination | 6641-6644 |
| Date Published | JUN |
| Type of Article | Article |
| Abstract | A novel Lewis acid catalyzed intermolecular cascade annulation of alkynols with alpha-ketoesters has been developed. This simple and efficient cascade annulation proceeds through a 5-exo-dig cyclization of alkynols followed by annulation with alpha-ketoester to provide a wide variety of unsaturated gamma-spiroketal-gamma-lactones (1,6-dioxaspiro[4.4]non-3-en-2-ones) related to many natural products. |
| DOI | 10.1039/c7cc03668j |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.567 |
Divison category:
Center for Material Characterization (CMC)
Organic Chemistry
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