Iron mediated oxidative ring opening-homocoupling of cyclopropanols: facile access to 1,6-diketones
| Title | Iron mediated oxidative ring opening-homocoupling of cyclopropanols: facile access to 1,6-diketones |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Shinde, RA, Shirsath, S, Muthukrishnan, M |
| Journal | ChemistrySelect |
| Volume | 10 |
| Issue | 18 |
| Pagination | e202501745 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 2365-6549 |
| Keywords | 1, 6-Diketone synthesis, C & horbar, C bond cleavage, cyclopropanols, Homocoupling, Iron mediated |
| Abstract | We have developed a new approach for the synthesis of 1,6-diketones via iron-catalyzed ring opening of cyclopropanol with a nontoxic, inexpensive iron catalyst under open-air conditions. This method eliminates the need for additives and employs tert-butanol as an eco-friendly solvent. This methodology allows rapid access to a variety of symmetrical 1,6-diketones under mild conditions. Preliminary mechanistic studies revealed the involvement of radical pathways. |
| DOI | 10.1002/slct.202501745 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.9 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)