Iron-catalyzed magnesium-mediated formal hydroformylation of alkynes and alkenes

TitleIron-catalyzed magnesium-mediated formal hydroformylation of alkynes and alkenes
Publication TypeJournal Article
Year of Publication2023
AuthorsTewari, T, Kumar, R, Chikkali, SH
JournalChemCatChem
Volume15
Issue3
Date PublishedFEB
Type of ArticleArticle
ISSN1867-3880
Keywordsaldehydes, alkenes, Alkynes, Hydroformylation, iron catalysis
Abstract

Alkynes and alkenes are routinely converted to corresponding synthetically versatile aldehydes using rhodium-catalyzed hydroformylation. However, rhodium is rare, precious, costly, and depleting at a considerably high rate. Reported here is iron-catalyzed, magnesium-mediated, formal hydroformylation of alkynes and alkenes in the absence of syngas. Readily available FeCl2 in the presence of alkyl magnesium halide, and dimethyl formamide, catalyzes hydroformylation of various alkynes and selectively produces alpha,beta-unsaturated aldehydes in good to excellent conversion. Mechanistic investigations revealed the presence of vinyl magnesium intermediate, the kinetic study disclosed the first-order dependence of the reaction on iron loading, and the control experiment authenticated the iron catalyst's homogeneous nature. The scope of this methodology was amplified, and 20 alkenes were examined. [Fe(acac)(3)] in the presence of ligand, alkyl magnesium halide, and dimethyl formamide catalyzed the hydroformylation of alkenes and displayed good to excellent conversion. An earth-abundant iron catalyst offering a syngas cylinder-free safe alternative to high-pressure hydroformylation has been reported.

DOI10.1002/cctc.202201394
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

5.497

Divison category: 
Polymer Science & Engineering
Database: 
Web of Science (WoS)

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