Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling
| Title | Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Balmik, AAnkur, Chinnathambi, S |
| Journal | European Journal of Cell Biology |
| Volume | 101 |
| Issue | 2 |
| Pagination | 151202 |
| Date Published | APR |
| Type of Article | Article |
| ISSN | 0171-9335 |
| Keywords | Actin, Cell migration, Cytoskeleton remodeling, HDAC6, Microtubules, Podosomes, ZnF UBP |
| Abstract | Cytoskeletal elements are the key players in cellular integrity, structure, signalling and migration. Each cytoskeletal element comprises of properties with respect to its structure and stability, which serve a specific array of functions. These structures are highly dynamic and regulated by modulation via direct interaction or post-translational modifications. HDAC6 is a cytoplasmic deacetylase known to regulate a wide range of cellular functions either through its deacetylase activity or direct interaction via its C-terminal ZnF UBP domain. HDAC6 has been widely studied for its role in aggresome formation, which acts as a protective mechanism upon protein aggregation. HDAC6 is known to play a critical role in the regulation of cytoskeletal elements-microtubules and actin filaments. This review summarizes the regulatory role of HDAC6 in cytoskeletal remodeling and dynamics of neuronal cells and its significance in neurodegenerative diseases. |
| DOI | 10.1016/j.ejcb.2022.151202 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.492 |
Divison category:
Biochemical Sciences