Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents
| Title | Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Nalla, V, Shaikh, A, Bapat, S, Vyas, R, Karthikeyan, M, Yogeeswari, P, Sriram, D, Muthukrishnan, M |
| Journal | Royal Society Open Science |
| Volume | 5 |
| Issue | 4 |
| Pagination | Article Number: 171750 |
| Date Published | APR |
| Abstract | A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The in vitro anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibit significant inhibition against Mycobacterium tuberculosis H37Rv strain with MIC in the range of 1.56-12.5 mu g ml(-1). Noticeably, compound 6s was the most potent compound in vitro with a MIC value of 1.56 mu g ml(-1). Molecular docking and chemoinformatics studies revealed that compound 6s displayed drug-like properties against the enoyl-acyl carrier protein reductase of M. tuberculosis further establishing its potential as a potent inhibitor. |
| DOI | 10.1098/rsos.171750 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.243 |
Divison category:
Organic Chemistry