Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions

TitleHydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions
Publication TypeJournal Article
Year of Publication2018
AuthorsPaula, S, Bhattacharya, AK
JournalOrganic & Biomolecular Chemistry
Volume16
Issue3
Pagination444-451
Date PublishedJAN
Type of ArticleArticle
ISSN1477-0520
Abstract

An efficient, transition-metal free and direct C-arylation of 3-hydroxychromone moieties in the presence of a base, air as an oxidant and arylhydrazines as arylating agents to furnish highly biologically active flavonols or 3-hydroxyflavones has been developed. We have further extended our methodology for the C-arylation of the 5-hydroxy pyran-4-one moiety. The role of the free hydroxyl group towards C-arylation has been delineated.

DOI10.1039/c7ob01929g
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)3.564
Divison category: 
Organic Chemistry

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