Highly efficient (R-X-R)-type carbamates as molecular transporters for cellular delivery
Title | Highly efficient (R-X-R)-type carbamates as molecular transporters for cellular delivery |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Patil, KM, Naik, RJ, Rajpal,, Fernandes, M, Ganguli, M, Kumar, VA |
Journal | Journal of the American Chemical Society |
Volume | 134 |
Issue | 17 |
Pagination | 7196-7199 |
Date Published | MAY |
ISSN | 0002-7863 |
Abstract | The (R-X-R) motif-containing arginine-rich peptides are among the most effective cell-penetrating peptides. The replacement of amide linkages in the (R-X-R) motif by carbamate linkages as in (r-ahx-r)(4) or (r-ahx-r-r-apr-r)(2) increases the efficacy of such oligomers several-fold. Internalization of these oligomers in mammalian cell lines occurs by an energy-independent process. These oligomers show efficient delivery of biologically active plasmid DNA into CHO-K1 cells. |
DOI | 10.1021/ja210026m |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 10.677 |
Divison category:
Organic Chemistry