Highly efficient one-pot multi-component synthesis of alpha-aminophosphonates and bis-alpha-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular eval
| Title | Highly efficient one-pot multi-component synthesis of alpha-aminophosphonates and bis-alpha-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular eval |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Mulla, SAbdul Rash, Pathan, MY, Chavan, SS, Gample, SP, Sarkar, D |
| Journal | RSC Advances |
| Volume | 4 |
| Issue | 15 |
| Pagination | 7666-7672 |
| Date Published | JAN |
| ISSN | 2046-2069 |
| Abstract | A highly efficient one-pot multi-component reaction (MCR) protocol over DTP/SiO2 has been developed for the synthesis of alpha-aminophosphonate derivatives (4a-x) in excellent yields. The alpha-aminophosphonate derivatives were for the first time evaluated for their antitubercular activity against the M. tuberculosis H37Ra (MTB) strain. An evaluation of the data on the cytotoxicity and antimicrobial activity shows that 4n and 4v are promising antitubercular agents. |
| DOI | 10.1039/c3ra45853a |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.98 |
Divison category:
Chemical Engineering & Process Development
Organic Chemistry