Helically structured peptide architecture engineered using dimedone as a rigid organic scaffold
| Title | Helically structured peptide architecture engineered using dimedone as a rigid organic scaffold |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Nadimpally, KC, Madica, K, Kotmale, AS, Gonnade, RG, Sanjayan, GJ |
| Journal | ChemistrySelect |
| Volume | 3 |
| Issue | 10 |
| Pagination | 2776-2780 |
| Date Published | MAR |
| Abstract | This communication reports the use of a rigid organic scaffold to attach two unsymmetrical peptide chains on a single carbon atom. The approach describes the step-by-step attachment of peptide chains to the rigid dimedone template (5,5-dimethyl-1,3-cyclohexanedione) - a molecular scaffold that directs orientation of the peptide helices in a well-defined arrangement via intra-molecular hydrogen bonding. The overall topology of the final molecules was studied using CD spectroscopy which suggested existence of helical architecture. |
| DOI | 10.1002/slct.201702856 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.505 |
Divison category:
Center for Material Characterization (CMC)
Central NMR Facility
Organic Chemistry
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