Gram-scale synthesis of (±)-tylophorine
| Title | Gram-scale synthesis of (±)-tylophorine |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Masal, DP, D. Reddy, S |
| Journal | Synlett |
| Volume | 36 |
| Issue | 5 |
| Pagination | 536-540 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0936-5214 |
| Keywords | alkaloids, Clemmensen reduction, decarboxylation, gram-scale synthesis, tylophorine |
| Abstract | We report a practical scalable synthesis of the natural product (+/-)-tylophorine by using an operationally simple protecting-group-free route from readily accessible starting materials. Synthesis of a cyclic N-acetyl diester compound through cyclization, followed by two key steps (decarboxylation and a Clemmensen reduction), provides access to the target molecule. |
| DOI | 10.1055/a-2351-4828 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)