Gold vs rhodium catalysis: tuning reactivity through catalyst control in the C-H alkynylation of isoquinolones
| Title | Gold vs rhodium catalysis: tuning reactivity through catalyst control in the C-H alkynylation of isoquinolones |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Shaikh, AC, Shinde, DR, Patil, NT |
| Journal | Organic Letters |
| Volume | 18 |
| Issue | 5 |
| Pagination | 1056-1059 |
| Date Published | MAR |
| ISSN | 1523-7060 |
| Abstract | A site-selective C-4/C-8 alkynylation of isoquinolones catalyzed by gold and rhodium complexes is reported. A broad range of synthetically useful functional groups (-F, -Cl, -Br, -CF3, -OMe, alkyl, etc.) were tolerated, providing an efficient and robust protocol for the synthesis either C-4- or C-8-alkynylated isoquinolones. |
| DOI | 10.1021/acs.orglett.6b00175 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Organic Chemistry