General strategy for a short and efficient synthesis of 3-hydroxy-4-methylprolines (HMP)
| Title | General strategy for a short and efficient synthesis of 3-hydroxy-4-methylprolines (HMP) |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Mohapatra, DK, Mondal, D, Chorghade, MS, Gurjar, MK |
| Journal | Tetrahedron Letters |
| Volume | 47 |
| Issue | 52 |
| Pagination | 9215-9219 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | 3, 4-disubstituted proline, Crimmins' aldol reaction, Garner's aldehyde, non-proteinogenic amino acids, RUO4 mediated oxidation |
| Abstract | The non-proteinogenic amino acid 3-hydroxy-4-methylproline (HMP) is an active constituent of some potent antimicrobials including echinocandins, nostopeptins, pneumocandins, sporiofungin and mulundocandins. A synthesis has been achieved in 10 steps with 29% overall yield; the Evans' aldol reaction using Crimmins' modified method was pivotal to the success of the strategy. (c) 2006 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2006.10.137 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.645 |
Divison category:
Organic Chemistry