General and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation
| Title | General and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Kumar, P, Dubey, A, Puranik, VG |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 8 |
| Issue | 22 |
| Pagination | 5074-5086 |
| Date Published | SEP |
| ISSN | 1477-0520 |
| Abstract | A novel, practical and efficient enantioselective synthesis of sphingoid bases, L-threo-[2S,3S]-sphinganine (safingol), L-threo-[2S,3S]-sphingosine, L-arabino-[2R,3S,4R] and L-xylo-[2R,3S,4S]-C(18)-phytosphingosine is described. The synthetic strategy features the Sharpless kinetic resolution and tethered aminohydroxylation (TA) as the key steps. |
| DOI | 10.1039/c0ob00117a |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.451 |
Divison category:
Center for Material Characterization (CMC)
Organic Chemistry