G-Quadruplexes as tools for synthetic biology

TitleG-Quadruplexes as tools for synthetic biology
Publication TypeJournal Article
Year of Publication2013
AuthorsAgarwala, P, Pandey, S, Maiti, S
Date PublishedNOV
KeywordsG-quadruplexes, ribozymes, synthetic biology, topology, zipcodes

With the potential to engineer biological systems, synthetic biology is an emerging field that combines various disciplines of sciences. It encompasses combinations of DNA, RNA and protein modules for constructing desired systems and the rewiring of existing signalling networks. Despite recent advances, this field still lags behind in the artificial reconstruction of cellular processes, and thus demands new modules and switches to create genetic circuits. The widely characterised noncanonical nucleic acid secondary structures, G-quadruplexes are promising candidates to be used as biological modules in synthetic biology. Structural plasticity and functional versatility are significant G-quadruplex traits for its integration into a biological system and for diverse applications in synthetic circuits.

Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)3.06
Divison category: 
Biochemical Sciences