Fungal mediated kinetic resolution of racemic acetates to (R)-alcohols using fusarium proliferatum
| Title | Fungal mediated kinetic resolution of racemic acetates to (R)-alcohols using fusarium proliferatum |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Jadhav, DD, Patil, HS, Chaya, PS, Thulasiram, HV |
| Journal | Tetrahedron Letters |
| Volume | 57 |
| Issue | 41 |
| Pagination | 4563-4567 |
| Date Published | OCT |
| Abstract | Fungal mediated kinetic resolution of seven acyclic/aromatic acetates was achieved using Fusarium proliferatum to furnish (R)-alcohols in high enantiomeric excess (>95%). The kinetic resolution was established as one-pot two-step de-esterification/oxidation biocatalytic process. Further, the preparative scale synthesis of (R)-(+)-1-phenylethanol was accomplished through de-esterification/oxidation of (+/-)-1-phenylethyl acetate using the whole cell of F. proliferatum NCIM 1105. (C) 2016 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2016.08.084 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry