Fungal mediated kinetic resolution of racemic acetates to (R)-alcohols using fusarium proliferatum

TitleFungal mediated kinetic resolution of racemic acetates to (R)-alcohols using fusarium proliferatum
Publication TypeJournal Article
Year of Publication2016
AuthorsJadhav, DD, Patil, HS, Chaya, PS, Thulasiram, HV
JournalTetrahedron Letters
Volume57
Issue41
Pagination4563-4567
Date PublishedOCT
Abstract

Fungal mediated kinetic resolution of seven acyclic/aromatic acetates was achieved using Fusarium proliferatum to furnish (R)-alcohols in high enantiomeric excess (>95%). The kinetic resolution was established as one-pot two-step de-esterification/oxidation biocatalytic process. Further, the preparative scale synthesis of (R)-(+)-1-phenylethanol was accomplished through de-esterification/oxidation of (+/-)-1-phenylethyl acetate using the whole cell of F. proliferatum NCIM 1105. (C) 2016 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2016.08.084
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)2.347
Divison category: 
Organic Chemistry