Functionalization of SBA-15 mesoporous materials using ``thiol-ene click'' michael addition reaction

TitleFunctionalization of SBA-15 mesoporous materials using ``thiol-ene click'' michael addition reaction
Publication TypeJournal Article
Year of Publication2011
AuthorsKumari, S, Malvi, B, Ganai, AKumar, Pillai, VK, Gupta, SSen
JournalJournal of Physical Chemistry C
Date PublishedSEP

Methacrylate-labeled SBA-15 has been successfully synthesized from calcined SBA-15 and commercially available 3-trichlorosilyl propylmethacrylate. This material undergoes efficient thiol-ene ``click reaction'' with a variety of both thiol and disulfide-containing substrates in aqueous and organic media. The products were thoroughly characterized by a variety of analytical techniques including multinuclear (C-13, Si-29) solid-state NMR, TG-DTA, and nitrogen adsorption desorption studies. Disulfide-containing substrates in which the TCEP-mediated reduction of the disulfide bond and its subsequent addition to the methacrylate group anchored in SBA-15 in one-pot were used to synthesize a silica-protein hybrid material composed of biotin-labeled SBA-15 and streptavidin. Electrochemically active material was synthesized from the reaction of ferrocene-containing thiol and the methacrylate-labeled SBA-15. The ease of synthesis for the methacrylate-labeled SBA-15 material together with its ability to undergo efficient chemoselective thiol-ene reaction would make it a very attractive platform for the development of covalently anchored enzymes and sensors.

Type of Journal (Indian or Foreign)


Impact Factor (IF)5.08
Divison category: 
Chemical Engineering & Process Development
Physical and Materials Chemistry